Dapoxetine attenuates testosterone-induced prostatic hyperplasia in rats by the regulation of inflammatory and apoptotic proteins

J Drug Deliv Sci Technol 43:160–171 Abdelkader DH et al (2018) Effect of process variables on formulation, in-vitro characterisation and subcutaneous delivery of insulin PLGA nanoparticles: an optimisation study.

• Not FDA approved in the US
• Approved in some other countries
• Prescription only medication
• Generic versions available
• Patent has expired
• Regulatory status varies
• Import restrictions apply
• Schedule III controlled substance?
• Prescription drug status
• Legal status varies by region
• Available in select markets
• Prescription required

J Drug Deliv Sci Technol 43:160–171 Abdelrahman FE et al (2017) Response surface optimization, ex vivo and in vivo investigation of nasal spanlastics for bioavailability enhancement and brain targeting of risperidone.

Dapoxetine Hydrochloride Tablets 30mg Technical Specification:

Busato W, Galindo C (2004) Topical anaesthetic use for treating premature ejaculation: a double-blind, randomized, placebo-controlled study. Callens C et al (2003) Rheological study on mucoadhesivity of some nasal powder formulations. Eur J Pharm Biopharm 55(3):323–328 Callens C et al (2003) Rheological study on mucoadhesivity of some nasal buy cheap dapoxetine powder formulations. Eur J Pharm Biopharm 55(3):323–328 Carani C et al (2005) Multicenter study on the prevalence of sexual symptoms in male hypo-and hyperthyroid patients. J Clin Endocrinol Metab 90(12):6472–6479 Carani C et al (2005) Multicenter study on the prevalence of sexual symptoms in male hypo-and hyperthyroid patients.

Stability study of PLGA NPs

J Clin Endocrinol Metab 90(12):6472–6479 Cheng Y-H et al (2002) Development of a novel nasal nicotine formulation comprising an optimal pulsatile and sustained plasma nicotine profile for smoking cessation. J Control Release 79(1–3):243–254 Cheng Y-H et al (2002) Development of a novel nasal nicotine formulation comprising an optimal pulsatile and sustained plasma nicotine profile for smoking cessation. J Control Release 79(1–3):243–254 Cho HJ, Park JW, Yoon IS, Kim DD (2014) Surface-modified solid lipid nanoparticles for oral delivery of docetaxel: enhanced intestinal absorption and lymphatic uptake. Cho HJ, Park JW, Yoon IS, Kim DD (2014) Surface-modified solid lipid nanoparticles for oral delivery of docetaxel: enhanced intestinal absorption and lymphatic uptake. Clark JT, Stanford University Department of Physiology (1983) Monoaminergic modulation of copulation in male rats Clark JT, Stanford University Department of Physiology (1983) Monoaminergic modulation of copulation in male rats Coolen LM (2005) Neural control of ejaculation.

Patients and Methods

J Comp Neurol 493(1):39–45 Coolen LM (2005) Neural control of ejaculation. J Comp Neurol 493(1):39–45 Crotts G, Park TG (1995) Preparation of porous and nonporous biodegradable polymeric hollow microspheres. J Control Release 35(2–3):91–105 Crotts G, Park TG (1995) Preparation of porous and nonporous biodegradable polymeric hollow microspheres. J Control Release 35(2–3):91–105 Crowe TP et al (2018) Mechanism of intranasal drug delivery directly to the brain. Crowe TP et al (2018) Mechanism of intranasal drug delivery directly to the brain. Int J Pharm 530(1–2):1–11 Abdelrahman FE et al (2017) Response surface optimization, ex vivo and in vivo investigation of nasal spanlastics for bioavailability enhancement and brain targeting of risperidone. Aboelwafa AA, El-Setouhy DA, Elmeshad AN (2010) Comparative study on the effects of some polyoxyethylene alkyl ether and sorbitan fatty acid ester surfactants on the performance of transdermal carvedilol proniosomal gel using experimental design.

Abou-Taleb HA et al (2024) In vitro and in vivo evaluation of isoxsuprine loaded invasomes for efficient treatment of diabetes‐accelerated atherosclerosis. J Drug Deliv Sci Technol 96:105686 Abou-Taleb HA et al (2024) In vitro and in vivo evaluation of isoxsuprine loaded invasomes for efficient treatment of diabetes‐accelerated atherosclerosis.

Increased risk of bleeding (see also Further information)

Drug Dev Ind Pharm 44(9):1443–1450 Gao H et al (2006) Conjugates of poly (dl-lactic acid) with ethylenediamino or diethylenetriamino bridged bis (β-cyclodextrin) s and their nanoparticles as protein delivery systems. J Control Release 112(3):301–311 Gao H et al (2006) Conjugates of poly (dl-lactic acid) with ethylenediamino or diethylenetriamino bridged bis (β-cyclodextrin) s and their nanoparticles as protein delivery systems. J Drug Deliv Sci Technol 96:105686 Ahmed YM et al (2019) Effects of ticagrelor, empagliflozin and tamoxifen against experimentally-induced vascular reactivity defects in rats in vivo and in vitro. Ahmed YM et al (2019) Effects of ticagrelor, empagliflozin and tamoxifen against experimentally-induced vascular reactivity defects in rats in vivo and in vitro. Ahmed YM et al (2022) Sustainable release of propranolol hydrochloride laden with biconjugated-ufasomes chitosan hydrogel attenuates cisplatin-induced sciatic nerve damage in in vitro/in vivo evaluation.

• Increased sensitivity to drug
• Monitor for falls in elderly
• Dose adjustment may be needed
• Watch for confusion and dizziness
• Polypharmacy increases risk
• Renal function declines with age
• Start with a low dose
• Monitor CNS effects closely
• Increased side effects common
• Consult geriatrician
• Safety in elderly limited
• Adjust based on frailty

Allémann E, Gurny R, Doelker E (1992) Preparation of aqueous polymeric nanodispersions by a reversible salting-out process: influence of process parameters on particle size. Int J Pharm 87(1–3):247–253 Allémann E, Gurny R, Doelker E (1992) Preparation of aqueous polymeric nanodispersions by a reversible salting-out process: influence of process parameters on particle size. Int J Pharm 87(1–3):247–253 Althof SE et al (2014) An update of the International Society of Sexual Medicine’s guidelines for the diagnosis and treatment of premature ejaculation (PE). J Sex Med 11(6):1392–1422 Althof SE et al (2014) An update of the International Society of Sexual Medicine’s guidelines for the diagnosis and treatment of premature ejaculation (PE). Asran AS, Henning S, Michler GH (2010) Polyvinyl alcohol–collagen–hydroxyapatite biocomposite nanofibrous scaffold: mimicking the key features of natural bone at the nanoscale level. Bacon CG et al (2002) Association of type and duration of diabetes with erectile dysfunction in a large cohort of men. Ballon JS, Feifel D (2006) A systematic review of modafinil: potential clinical uses and mechanisms of action. J Clin Psychiatry 67(4):554–566 Ballon JS, Feifel D (2006) A systematic review of modafinil: potential clinical uses and mechanisms of action. J Clin Psychiatry 67(4):554–566 Bancroft JD, Gamble M (2008) Theory and practice of histological techniques. Bancroft JD, Gamble M (2008) Theory and practice of histological techniques. Beck-Broichsitter M et al (2010) Preparation of nanoparticles by solvent displacement for drug delivery: a shift in the “ouzo region” upon drug loading. Eur J Pharm Sci 41(2):244–253 Beck-Broichsitter M et al (2010) Preparation of nanoparticles by solvent displacement for drug delivery: a shift in the “ouzo region” upon drug loading. Eur J Pharm Sci 41(2):244–253 Belliveau F, Richter L (1970) Understanding human sexual inadequacy, by Fred Belliveau and Lin Richter. Foreword by William H.

Masters and Virginia E. Johnson. Belliveau F, Richter L (1970) Understanding human sexual inadequacy, by Fred Belliveau and Lin Richter.

Blanco R et al (1990) Dysfunctional penile cholinergic nerves in diabetic impotent men. Borgia SL et al (2005) Lipid nanoparticles for skin penetration enhancement—correlation to drug localization within the particle matrix as determined by fluorescence and parelectric spectroscopy. J Control Release 110(1):151–163 Borgia SL et al (2005) Lipid nanoparticles for skin penetration enhancement—correlation to drug localization within the particle matrix as determined by fluorescence and parelectric spectroscopy. J Control Release 110(1):151–163 Busato W, Galindo C (2004) Topical anaesthetic use for treating premature ejaculation: a double-blind, randomized, placebo-controlled study. Busato W, Galindo C (2004) Topical anaesthetic use for treating premature ejaculation: a double-blind, randomized, placebo-controlled study. Callens C et al (2003) Rheological study on mucoadhesivity of some nasal powder formulations.

Cited by (32)

J Drug Deliv Sci Technol 43:160–171 Abdelkader DH et al (2018) Effect of process variables on formulation, in-vitro characterisation and subcutaneous delivery of insulin PLGA nanoparticles: an optimisation study. J Drug Deliv Sci Technol 43:160–171 Abdelrahman FE et al (2017) Response surface optimization, ex vivo and in vivo investigation of nasal spanlastics for bioavailability enhancement and brain targeting of risperidone. Int J Pharm 530(1–2):1–11 Abdelrahman FE et al (2017) Response surface optimization, ex vivo and in vivo investigation of nasal spanlastics for bioavailability enhancement and brain targeting of risperidone. Aboelwafa AA, El-Setouhy DA, Elmeshad AN (2010) Comparative study on the effects of some polyoxyethylene alkyl ether and sorbitan fatty acid ester surfactants on the performance of transdermal carvedilol proniosomal gel using experimental design. Abou-Taleb HA et al (2024) In vitro and in vivo evaluation of isoxsuprine loaded invasomes for efficient treatment of diabetes‐accelerated atherosclerosis.

QUALITATIVE AND QUANTITATIVE COMPOSITION:

J Drug Deliv Sci Technol 96:105686 Abou-Taleb HA et al (2024) In vitro and in vivo evaluation of isoxsuprine loaded invasomes for efficient treatment of diabetes‐accelerated atherosclerosis. J Drug Deliv Sci Technol 96:105686 Ahmed YM et al (2019) Effects of ticagrelor, empagliflozin and tamoxifen against experimentally-induced vascular reactivity defects in rats in vivo and in vitro. Ahmed YM et al (2019) Effects of ticagrelor, empagliflozin and tamoxifen against experimentally-induced vascular reactivity defects in rats in vivo and in vitro. Ahmed YM et al (2022) Sustainable release of propranolol hydrochloride laden with biconjugated-ufasomes chitosan hydrogel attenuates cisplatin-induced sciatic nerve damage in in vitro/in vivo evaluation. Allémann E, Gurny R, Doelker E (1992) Preparation of aqueous polymeric nanodispersions by a reversible salting-out process: influence of process parameters on particle size.

Corresponding author

Int J Pharm 87(1–3):247–253 Allémann E, Gurny R, Doelker E (1992) Preparation of aqueous polymeric nanodispersions by a reversible salting-out process: influence of process parameters on particle size. Int J Pharm 87(1–3):247–253 Althof SE et al (2014) An update of the International Society of Sexual Medicine’s guidelines for the diagnosis and treatment of premature ejaculation (PE). J Sex Med 11(6):1392–1422 Althof SE et al (2014) An update of the International Society of Sexual Medicine’s guidelines for the diagnosis and treatment of premature ejaculation (PE). Asran AS, Henning S, Michler GH (2010) Polyvinyl alcohol–collagen–hydroxyapatite biocomposite nanofibrous scaffold: mimicking the key features of natural bone at the nanoscale level. Bacon CG et al (2002) Association of type and duration of diabetes with erectile dysfunction in a large cohort of men. Eur J Pharm Biopharm 55(3):323–328 Callens C et al (2003) Rheological study on mucoadhesivity of some nasal buy cheap dapoxetine powder formulations. Eur J Pharm Biopharm 55(3):323–328 Carani C et al (2005) Multicenter study on the prevalence of sexual symptoms in male hypo-and hyperthyroid patients. J Clin Endocrinol Metab 90(12):6472–6479 Carani C et al (2005) Multicenter study on the prevalence of sexual symptoms in male hypo-and hyperthyroid patients. J Clin Endocrinol Metab 90(12):6472–6479 Cheng Y-H et al (2002) Development of a novel nasal nicotine formulation comprising an optimal pulsatile and sustained plasma nicotine profile for smoking cessation. J Control Release 79(1–3):243–254 Cheng Y-H et al (2002) Development of a novel nasal nicotine formulation comprising an optimal pulsatile and sustained plasma nicotine profile for smoking cessation. J Control Release 79(1–3):243–254 Cho HJ, Park JW, Yoon IS, Kim DD (2014) Surface-modified solid lipid nanoparticles for oral delivery of docetaxel: enhanced intestinal absorption and lymphatic uptake. Cho HJ, Park JW, Yoon IS, Kim DD (2014) Surface-modified solid lipid nanoparticles for oral delivery of docetaxel: enhanced intestinal absorption and lymphatic uptake. Clark JT, Stanford University Department of Physiology (1983) Monoaminergic modulation of copulation in male rats Clark JT, Stanford University Department of Physiology (1983) Monoaminergic modulation of copulation in male rats Coolen LM (2005) Neural control of ejaculation. J Comp Neurol 493(1):39–45 Coolen LM (2005) Neural control of ejaculation. J Comp Neurol 493(1):39–45 Crotts G, Park TG (1995) Preparation of porous and nonporous biodegradable polymeric hollow microspheres. J Control Release 35(2–3):91–105 Crotts G, Park TG (1995) Preparation of porous and nonporous biodegradable polymeric hollow microspheres. J Control Release 35(2–3):91–105 Crowe TP et al (2018) Mechanism of intranasal drug delivery directly to the brain. Crowe TP et al (2018) Mechanism of intranasal drug delivery directly to the brain.

• Dose adjustment may be necessary
• Reduced clearance in renal failure
• Monitor for increased side effects
• Lower starting dose recommended
• Consult a nephrologist if needed
• Risk of drug accumulation
• Watch for dizziness and falls
• Adjust frequency of dosing
• Do not exceed recommended limit
• Safety data is limited in renal impairment
• Adjust based on glomerular filtration rate
• Use with caution in moderate impairment

Cui F et al (2005) Preparation and characterization of melittin-loaded poly (DL-lactic acid) or poly (DL-lactic-co-glycolic acid) microspheres made by the double emulsion method. J Control Release 107(2):310–319 Cui F et al (2005) Preparation and characterization of melittin-loaded poly (DL-lactic acid) or poly (DL-lactic-co-glycolic acid) microspheres made by the double emulsion method. J Control Release 107(2):310–319 De Jong T et al (2005) Effects of chronic paroxetine pretreatment on (±)-8-hydroxy-2-(di-n-propyl-amino) tetralin induced c-fos expression following sexual behavior. De Jong T et al (2005) Effects of chronic paroxetine pretreatment on (±)-8-hydroxy-2-(di-n-propyl-amino) tetralin induced c-fos expression following sexual behavior. de Jong TR et al (2006) Serotonin and the neurobiology of the ejaculatory threshold. Neurosci Biobehav Rev 30(7):893–907 de Jong TR et al (2006) Serotonin and the neurobiology of the ejaculatory threshold.

a. State-of-the-Art Manufacturing

Ballon JS, Feifel D (2006) A systematic review of modafinil: potential clinical uses and mechanisms of action. J Clin Psychiatry 67(4):554–566 Ballon JS, Feifel D (2006) A systematic review of modafinil: potential clinical uses and mechanisms of action. J Clin Psychiatry 67(4):554–566 Bancroft JD, Gamble M (2008) Theory and practice of histological techniques. Bancroft JD, Gamble M (2008) Theory and practice of histological techniques. Beck-Broichsitter M et al (2010) Preparation of nanoparticles by solvent displacement for drug delivery: a shift in the “ouzo region” upon drug loading.

Phosphodiesterase 5 inhibitors

Eur J Pharm Sci 41(2):244–253 Beck-Broichsitter M et al (2010) Preparation of nanoparticles by solvent displacement for drug delivery: a shift in the “ouzo region” upon drug loading. Eur J Pharm Sci 41(2):244–253 Belliveau F, Richter L (1970) Understanding human sexual inadequacy, by Fred Belliveau and Lin Richter. Foreword by William H. Masters and Virginia E. Johnson.

Gene Information

Belliveau F, Richter L (1970) Understanding human sexual inadequacy, by Fred Belliveau and Lin Richter. Blanco R et al (1990) Dysfunctional penile cholinergic nerves in diabetic impotent men. Borgia SL et al (2005) Lipid nanoparticles for skin penetration enhancement—correlation to drug localization within the particle matrix as determined by fluorescence and parelectric spectroscopy. J Control Release 110(1):151–163 Borgia SL et al (2005) Lipid nanoparticles for skin penetration enhancement—correlation to drug localization within the particle matrix as determined by fluorescence and parelectric spectroscopy. J Control Release 110(1):151–163 Busato W, Galindo C (2004) Topical anaesthetic use for treating premature ejaculation: a double-blind, randomized, placebo-controlled study. Neurosci Biobehav Rev 30(7):893–907 Dinsmore WW, Wyllie MG (2009) PSD502 improves ejaculatory latency, control and sexual satisfaction when applied topically 5 min before intercourse in men with premature ejaculation: results of a phase III, multicentre, double-blind, placebo-controlled study. Dinsmore WW, Wyllie MG (2009) PSD502 improves ejaculatory latency, control and sexual satisfaction when applied topically 5 min before intercourse in men with premature ejaculation: results of a phase III, multicentre, double-blind, placebo-controlled study. El Menshawe SF et al (2019) Transdermal delivery of fluvastatin sodium via tailored spanlastic nanovesicles: mitigated Freund’s adjuvant-induced rheumatoid arthritis in rats through suppressing p38 MAPK signaling pathway. El-Nabarawi MA et al (2016a) Transbuccal delivery of betahistine dihydrochloride from mucoadhesive tablets with a unidirectional drug flow: in vitro, ex vivo and in vivo evaluation. El-Nabarawi MA et al (2016b) Transbuccal delivery of betahistine dihydrochloride from mucoadhesive tablets with a unidirectional drug flow: in vitro, ex vivo and in vivo evaluation. Feng S-S, Huang G (2001) Effects of emulsifiers on the controlled release of paclitaxel (Taxol®) from nanospheres of biodegradable polymers.

Neuromuscular blocking drugs (NMBDs)

Cui F et al (2005) Preparation and characterization of melittin-loaded poly (DL-lactic acid) or poly (DL-lactic-co-glycolic acid) microspheres made by the double emulsion method. J Control Release 107(2):310–319 Cui F et al (2005) Preparation and characterization of melittin-loaded poly (DL-lactic acid) or poly (DL-lactic-co-glycolic acid) microspheres made by the double emulsion method. J Control Release 107(2):310–319 De Jong T et al (2005) Effects of chronic paroxetine pretreatment on (±)-8-hydroxy-2-(di-n-propyl-amino) tetralin induced c-fos expression following sexual behavior. De Jong T et al (2005) Effects of chronic paroxetine pretreatment on (±)-8-hydroxy-2-(di-n-propyl-amino) tetralin induced c-fos expression following sexual behavior. de Jong TR et al (2006) Serotonin and the neurobiology of the ejaculatory threshold.

Curr. Opin. Urol.

Neurosci Biobehav Rev 30(7):893–907 de Jong TR et al (2006) Serotonin and the neurobiology of the ejaculatory threshold. Neurosci Biobehav Rev 30(7):893–907 Dinsmore WW, Wyllie MG (2009) PSD502 improves ejaculatory latency, control and sexual satisfaction when applied topically 5 min before intercourse in men with premature ejaculation: results of a phase III, multicentre, double-blind, placebo-controlled study. Dinsmore WW, Wyllie MG (2009) PSD502 improves ejaculatory latency, control and sexual satisfaction when applied topically 5 min before intercourse in men with premature ejaculation: results of a phase III, multicentre, double-blind, placebo-controlled study. El Menshawe SF et al (2019) Transdermal delivery of fluvastatin sodium via tailored spanlastic nanovesicles: mitigated Freund’s adjuvant-induced rheumatoid arthritis in rats through suppressing p38 MAPK signaling pathway. El-Nabarawi MA et al (2016a) Transbuccal delivery of betahistine dihydrochloride from mucoadhesive tablets with a unidirectional drug flow: in vitro, ex vivo and in vivo evaluation.

ESM1 (download ZIP )

El-Nabarawi MA et al (2016b) Transbuccal delivery of betahistine dihydrochloride from mucoadhesive tablets with a unidirectional drug flow: in vitro, ex vivo and in vivo evaluation. Feng S-S, Huang G (2001) Effects of emulsifiers on the controlled release of paclitaxel (Taxol®) from nanospheres of biodegradable polymers. J Control Release 71(1):53–69 Feng S-S, Huang G (2001) Effects of emulsifiers on the controlled release of paclitaxel (Taxol®) from nanospheres of biodegradable polymers. J Control Release 71(1):53–69 Fouad SA et al (2018) Novel instantly-dispersible nanocarrier powder system (IDNPs) for intranasal delivery of dapoxetine hydrochloride: in-vitro optimization, ex-vivo permeation studies, and in-vivo evaluation. Drug Dev Ind Pharm 44(9):1443–1450 Fouad SA et al (2018) Novel instantly-dispersible nanocarrier powder system (IDNPs) for intranasal delivery of dapoxetine hydrochloride: in-vitro optimization, ex-vivo permeation studies, and in-vivo evaluation. J Control Release 71(1):53–69 Feng S-S, Huang G (2001) Effects of emulsifiers on the controlled release of paclitaxel (Taxol®) from nanospheres of biodegradable polymers. J Control Release 71(1):53–69 Fouad SA et al (2018) Novel instantly-dispersible nanocarrier powder system (IDNPs) for intranasal delivery of dapoxetine hydrochloride: in-vitro optimization, ex-vivo permeation studies, and in-vivo evaluation. Drug Dev Ind Pharm 44(9):1443–1450 Fouad SA et al (2018) Novel instantly-dispersible nanocarrier powder system (IDNPs) for intranasal delivery of dapoxetine hydrochloride: in-vitro optimization, ex-vivo permeation studies, and in-vivo evaluation. Drug Dev Ind Pharm 44(9):1443–1450 Gao H et al (2006) Conjugates of poly (dl-lactic acid) with ethylenediamino or diethylenetriamino bridged bis (β-cyclodextrin) s and their nanoparticles as protein delivery systems. J Control Release 112(3):301–311 Gao H et al (2006) Conjugates of poly (dl-lactic acid) with ethylenediamino or diethylenetriamino bridged bis (β-cyclodextrin) s and their nanoparticles as protein delivery systems.