How Scream Cream Makes Menopause Sex Better

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• Viagra cream is a topical treatment designed for erectile dysfunction.
• It contains the active ingredient sildenafil.
• Applied directly to the skin for quick absorption.
• Typically used before sexual activity for increased blood flow.
• Often marketed as an alternative to oral tablets.
• May have fewer systemic side effects than pills.
• Application areas usually include the inner thigh or genitals.
• Effectiveness can vary depending on individual response.
• Needs to be applied about 15-30 minutes prior to sex.
• Not suitable for people allergic to sildenafil or similar drugs.

Explore your whole life health with expert interviews, stories from real people, health innovations, research, products, and fun recommendations.

Sexual dysfunction in women has long hovered at the edge of clinical conversations, recognized but under-investigated, named but rarely prioritized.

Is topical viagra worth trying?

There’s desire [and] there’s arousal, just like in men.” Johnson, who has worked in women’s health innovation for over two decades, hopes this product not only serves women’s sexual health but also normalizes it as an integral pillar of their whole health. In the meantime, DARE to PLAY joins a sparse field of prescription arousal products for women. Sprout Pharmaceuticals’ Addyi, a pill to treat hypoactive sexual desire disorder in premenopausal women, faced an uphill battle before receiving FDA approval in 2015. As Dr. Sadaf Lodhi, a sex counselor and board-certified OB-GYN, told Flow Space, women have long felt obligated to normalize low libido and painful sex.

Can men use scream cream?

Ten years ago, no one was talking about libido as much. [Women] don’t need to settle for sex being painful or a weekend viagra decreased libido if it’s bothering them,” she says. “To want sex is to have sex worth wanting. I always say to my patients, ‘if you’re not experiencing pleasure with intimacy, then you’re not going to want it.’” Johnson says that successfully creating the formulation, ensuring it could work in 10 minutes, was integral to getting the cream to market to serve women’s needs. “Decades of underfunding and underdevelopment have also led many women to deprioritize their sexual health or, worse, turn to risky, unregulated treatments that, more and more, are being advertised as safe and effective,” says Johnson. While male sexual health became a pharmaceutical frontier with the approval of Viagra in 1998, female arousal disorders remained in a therapeutic vacuum.

Until recently, much of what passed for treatment viagra click and collect was indirect: hormone replacement, psychotherapy, lubricants.

• Viagra cream is often used by men seeking a discreet option.
• It is a semi-liquid formulation that enhances intimacy.
• The cream may be combined with other topical agents.
• Its shelf life depends on storage conditions.
• Usually available through online vendors, sometimes unregulated.
• The safety and efficacy of Viagra cream are not FDA-approved.
• Users should consult a healthcare provider before use.
• Possible side effects include skin irritation or headache.
• The dosage can vary depending on the product formulation.
• Use with caution if taking nitrates or other medications.

What was missing was not only efficacy, but attention. In 2024, a multicenter pilot trial of topical sildenafil 3.6% cream in women with Female Sexual Arousal Disorder (FSAD) (PMC) reported statistically significant improvements in subjective arousal, genital engorgement, and—perhaps most strikingly, body-image confidence. The findings were most pronounced in women who began the study with high levels of sexual distress.

Up to 40% of women report low sexual desire or interest, and women are 2-3x more likely than men to experience a decline in sex drive as they age

These patients also had a higher mean improvement in SFQ28 Desire and Orgasm domain scores, as well as significantly decreased sexual distress and interpersonal difficulties as assessed by FSDS-DAO questions 3, 5, and 10.2 “As more women speak openly about their sexual health, the need for research-backed solutions has never been greater,” said Irwin Goldstein, MD, director of San Diego Sexual Medicine in California and a founder of the International Society for the Study of Women’s Sexual Health in the news release. “Daré’s commitment to both clinical integrity and timely access ensures women who need it don’t have to wait to benefit from this innovation.”1 DARE to PLAY sildenafil cream now available for pre-order by prescription: First evidence-based topical arousal cream for women begins commercial rollout in select states via 503B outsourcing facility. Preliminary efficacy of topical sildenafil cream for the treatment of female sexual arousal disorder: A randomized controlled trial. "With women, it has been viewed as more complicated .. but it's not." Today, doctors can begin prescribing a first-of-its-kind arousal cream for women.

Let's do it.

Daré Bioscience, a biotech company focused solely on women’s health innovations, launched DARE to PLAY™, a cream to improve women’s sexual health and desire. The product, which is now available in some states through prescription, is made with the same active ingredient as Viagra: sildenafil. Viagra was FDA-approved in 1998 to treat erectile dysfunction in men, and nearly thirty years later, momentum to create similar products for women has lagged far behind. At least one in five women will experience low libido or struggle with arousal during sex; for women in midlife, low libido is more common amid hormonal fluctuations. “We knew from existing research that the same active ingredient in Viagra could have similar benefits for women, but when taken as a pill, it caused unwanted side effects,” CEO of Daré Bioscience Sabrina Johnson tells Flow Space.

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“So, we asked a simple question: what if we could deliver it differently?” The topical cream formulation works by increasing blood flow before a sexual activity by opening and relaxing blood vessels in the clitoris and vulva, where the cream is applied. Johnson hopes this launch marks a shift toward closing the gender desire gap. “Men were very loud about the fact that it was so critical to their sexual function and sexual activity to be able to have an erection. With women, it has been viewed as more complicated … but it’s not,” says Johnson. “It’s really not that much more complicated. It was measurable, meaningful, and deeply suggestive.

Interested, but not quite ready?

Sildenafil citrate for female sexual arousal disorder: a future possibility? “The Role of Local Vaginal Estrogen for Treatment of Vaginal Atrophy in Postmenopausal Women.” Menopause, vol. “Vaginal Estrogen Use and Chronic Disease Risk in the Nurses' Health Study.” Menopause, vol. DARE to PLAY is a topical sildenafil cream enhancing female arousal, available in select states as a compounded product while awaiting FDA approval. Clinical trials showed improved arousal sensation scores, though not statistically significant compared to placebo, with significant benefits in a subset of women with FSAD.

CONVENIENT & DISCREET

Daré Bioscience said the sildenafil cream’s availability will expand to other states throughout December 2025 and early 2026. DARE to PLAY, a proprietary topical arousal cream designed to enhance genital blood flow and arousal response in women, can now be prescribed in select states, manufacturer Daré Bioscience, Inc announced in a news release.1 “When Viagra [sildenafil citrate] was approved in 1998, it revolutionized sexual medicine for men. But for women, comparable progress on enhancing the natural arousal sensations has stalled for nearly 3 decades,” said Sabrina Martucci Johnson, President and CEO of Daré Bioscience, in the news release. “We believe DARE to PLAY represents a long overdue correction, giving women an option to reconnect with their own bodies, their pleasure, and their confidence, using science that finally recognizes their needs.”1 As the company continues the process to seek FDA approval of the sildenafil cream formulation, it is making the cream available in the form of a Section 503B compounded product. Although the sildenafil cream is manufactured “in an outsourcing facility subject to FDA inspection and under current Good Manufacturing Practice regulations,” Daré Bioscience noted that compounded drugs are not FDA approved or evaluated by the agency for “safety, effectiveness, or quality.”1 DARE to PLAY is currently available for prescription for pre-order in Connecticut, Florida, Indiana, Missouri, New Jersey, Oregon, Pennsylvania, Rhode Island, and Utah.

Control of lipolysis by natriuretic peptides and cyclic GMP

Daré Bioscience said the sildenafil cream’s availability will expand to other states throughout December 2025 and early 2026.1 DARE to PLAY has been evaluated in several studies, including a phase 2b randomized controlled trial (NCT04948151), the results of which were published in Obstetrics & Gynecology. In that study, 200 women with female sexual arousal disorder (FSAD) were randomly assigned to receive the sildenafil cream or placebo cream. The co-primary efficacy end points included change from baseline to week 12 in the Arousal Sensation domain of the Sexual Function Questionnaire (SFQ28), as well as question 14 of the Female Sexual Distress Scale—Desire, Arousal, Orgasm (FSDS-DAO).2 Greater improvement in SFQ28 Arousal Sensation domain scores was observed in patients receiving sildenafil cream, although “there were no statistically significant differences between sildenafil and placebo cream users in the coprimary and secondary efficacy end points,” wrote the authors. The investigators also conducted an exploratory post hoc analysis evaluating a subset of the intention-to-treat population who had a diagnosis of FSDD viagra 100mg with or without concomitant decreased desire. In this subset, significant increases in SFQ28 Arousal Sensation domain score were seen vs the placebo group. This is of great importance, because FSAD is more than a vascular issue.

It is where biology and psychology meet: where impaired genital responsiveness collides with internalized shame, fear of touch, or simply the loss of ease within one’s own skin.

• The development of Viagra cream aims to improve convenience.
• It may allow for quicker libido response times.
• Compatibility with condom use varies; check labels.
• Some formulations are designed for extended release.
• Users with sensitive skin should opt for hypoallergenic versions.
• The safety profile of long-term topical use is not well-established.
• Dosage may be adjusted based on individual needs.
• Always follow storage and usage instructions carefully.
• Using too much can lead to unwanted side effects.
• Disclosure with a healthcare professional is recommended.

For many women, the inability to feel arousal is not just about friction or blood flow. It’s about invisibility clinical, relational, and even personal.

Science-backed ingredients

“I think we’ll start to see women put more pressure on companies to deliver real, science-backed solutions.” While Daré Bioscience’s cream is not currently FDA-approved, Johnson has her sights on approval in the future. For now, the product is available as a compounded topical through Section 503B of the Federal Food, Drug, and Cosmetic Act (FDCA), meaning it is produced at an FDA-registered outsourcing facility. The cream underwent toxicology testing; a randomized, placebo-controlled study; and was manufactured under cGMP requirements. “What we’re hoping we’re doing is a correction to the system,” Johnson says. It’s not niche for half the population. Not only did the cream improve objective sexual function, it also seemed to change how participants felt about their own bodies.

Women reported increased genital awareness, less self-consciousness during intimacy, and greater initiation of sexual activity (journals.lww.com).

• Viagra cream offers potential for personalized dosing.
• It might be used in combinations with other topical therapies.
• Some formulations include numbing agents for comfort.
• The market is driven by demand for non-invasive ED solutions.
• Long-term safety data is currently lacking.
• Its use is often driven by convenience and privacy.
• The cream's active ingredient is usually sildenafil, similar to tablets.
• Some products claim to enhance libido beyond ED treatment.
• Use of Viagra cream does not replace professional diagnosis.
• Monitoring by healthcare providers is advised when used regularly.